The replacement for Reds ace and teammate Johnny Cueto on the NL roster, Simon took over for Clayton Kershaw and worked the bottom of the third. The right-hander pitched a scoreless inning with one hit -- a leadoff single lofted to right field from Jeter on a full-count pitch.
"It was big," Simon said of his first All-Star Game experience. "I faced Derek Jeter in his final All-Star Game. … I just feel happy. My family has seen me pitch in the All-Star Game. I'm really proud of myself."
The rest of Simon's batters were a imposing trio for any pitcher to deal with -- Mike Trout, Robinson Cano and Miguel Cabrera.
After a wild pitch to Trout moved Jeter to second base, Simon struck out Cano with an 86-mph pitch. A 76-mph 3-2 curveball to Cabrera was lined hard, but right to Troy Tulowitzki at shortstop to end the inning.
"I thought he did great," said Reds All-Star third baseman Todd Frazier, who walked in his lone plate appearance. "He got a strikeout. He got Cabrera to line out. I was happy for him."
Of Simon's 22 pitches, 14 were strikes.
"I just tried to put a zero on the board," Simon said. "That's my first experience. I just tried to keep the game close. It's nothing different. I just tried to do my best and that's what I did."
In his 14th and final All-Star Game, Jeter finished 2-for-2 before he exited. He led off the game with a double off Cardinals ace Adam Wainwright, who told reporters he grooved pitches over the plate to the soon-to-be retired Yankees captain, though he later backed off from his earlier comments. Simon did not take the same approach.
"I threw another fastball, 3-2, and he got a blooper in. It was OK," Simon said. "I tried to get him out, but if he got a base hit, it's no big deal. It's the All-Star Game. I'm happy for him."
It's been a breakout season for Simon, a reliever who began the year as a replacement in the Cincinnati rotation for Mat Latos. He earned his spot on the NL team by going 12-3 with a 2.70 ERA in 18 starts.
Mark Sheldon is a reporter for MLB.com. Read his blog, Mark My Word, and follow him on Twitter @m_sheldon. This story was not subject to the approval of Major League Baseball or its clubs.