Several players were placed in their typical spots in the order -- Brandon Phillips leading off, Joey Votto hitting third, Jay Bruce in the five-hole. But three Reds were batting in unfamiliar territory.
Filling in for an injured Ryan Ludwick in left field, Xavier Paul was hitting second, a spot he hasn't occupied all season and one he's only hit from in 33 games in his four-year career.
Rookie Todd Frazier took over Ludwick's duties as the cleanup hitter, getting just his second start there after testing the waters for the first time in his Major League career Thursday in Chicago.
"It didn't work out so well," said Frazier, who went 0-for-5 in that game. "It's pretty cool though. I'm excited about it."
Fellow rookie Zack Cozart, normally a leadoff or No. 2 hitter, hit eighth for the first time in his career.
Cozart made his first start Friday since straining his left oblique muscle, and acting manager Chris Speier said the move to the No. 8 spot will hopefully allow Cozart to settle back in without any added stress.
"I had him in the two-hole [Friday], but today I said, 'Let's have him relax a little bit, take some of the pressure off and let him get back in the swing of things,'" Speier said. "We'll see how that goes."
The Reds might as well try everything. Entering Saturday, they had scored the fourth fewest runs (56) in the Major Leagues in September, posting a 10-8 record.
Frazier, who has hit in every spot except second in his career, said the lineup shuffle doesn't bother him, but he hopes it works.
"It's whatever to me, to be honest because I never know where I'm going to be," Frazier said. "Whether I'm batting seventh, fourth, first, I still have the same mindset -- get on base and try to do some damage."