In the bottom of the fourth inning, he was hit on the right hand by a pitch from Brewers left-hander CC Sabathia. Bruce left in the sixth for X-rays, which a team spokesman said were negative.
Bruce, a rookie who's considered one of the key pieces in the Reds' future, remained in the ballgame for the fifth inning before being replaced by Corey Patterson in the sixth.
He entered the game with a .260 average, 21 homers and 52 RBIs.
Justice B. Hill is a senior writer for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.