Hamilton was selected as one of eight infielders for the U.S. Team, and Lotzkar, a native of Canada, was one of 10 pitchers named to the World Team.
Hamilton, who was taken in the second round by the Reds out of high school in the 2009 First-Year Player Draft, has seen success as a switch-hitter for Class A Advanced Bakersfield, with his .322 average through Tuesday leading all Reds Minor Leaguers.
The 21-year-old speedster also swiped 80 stolen bases in his first 66 games this season and is on pace to far exceed the 103 bases he stole last season.
Hamilton is ranked by MLB.com as the Reds' top prospect.
Lotzkar, who earned a promotion to Double-A Pensacola after just five starts with Bakersfield, holds a 3-2 record through seven starts with the Blue Wahoos, having struck out 49 while walking 22 in 41 2/3 innings.
The 22-year-old righty was part of the Canadian national team that won the bronze medal at the 2011 Baseball World Cup and the Gold Medal at the 2011 Pan-American Games.
Lotzkar has a 2.78 ERA in 12 total starts this season, and is ranked as Cincinnati's No. 18 prospect, according to MLB.com.
The 14th annual Sirius XM All-Star Futures Game can be seen live on MLB.TV, ESPN2 and ESPN2 HD and followed live on MLB.com's Gameday on Sunday, July 8, at 5 p.m. ET. In addition, XM Radio will broadcast play-by-play coverage of the event live on MLB Network Radio XM 89. MLB.com will also provide complete coverage before, during and after the game. Fans can stay updated by following @MLBFutures on Twitter and can send/receive tweets to/from the U.S. and World team dugouts during the game by following @USDugout and @WorldDugout.
Hamilton and Lotzkar join a lofty list of current Reds who have been featured in past Futures Games.
Pitchers Homer Bailey (U.S., 2006) and Mat Latos (U.S., '09), catcher Devin Mesoraco (U.S., '11), second baseman Brandon Phillips (U.S., '02), first baseman Joey Votto (World, '06, '07) and outfielders Jay Bruce (U.S., '07), Chris Heisey (U.S., '09) and Ryan Ludwick (U.S., '01) have all seen action in the Futures Game since its debut in 1999.
Major League Baseball -- along with the Major League Baseball Scouting Bureau, MLB.com, Baseball America and the 30 Major League baseball clubs -- selected the 25-man rosters.
Mark Clements is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.